Company overview:

Computation is revolutionizing drug discovery. Advances in big chemical data, massive computing power, artificial intelligence, and molecular dynamics simulation are changing the way we develop new drugs. At 1910 Genetics, we put computation at the heart of drug discovery, blending expertise in computational chemistry, structural biology, pharmacology, genetics, data science, and software engineering to develop drugs for previously undruggable targets.

You are someone we can count on to…
  • Act as both an Individual Contributor (IC), who can roll up her sleeve, and play an important role in our mission to use AI/ML to develop drugs against historically difficult disease targets, as well as a Leader who can build and grow the Computational Chemistry team
You will own…
  • All aspects of the company’s computational  chemistry efforts across therapeutic modalities, disease targets, and indications
  • Implementation of computational chemistry toolkits (e.g. MOE, MolSoft, OpenEye, Schrodinger) to run virtual screening campaigns to rapidly identify drug candidates for further development
  • The process for proactively seeking and incorporating input from Medicinal Chemists into virtual screening campaigns to arrive at virtual hits with high probability of synthesis and clinical utility
  • Effective collaboration with the ML Engineering and AI Research team by providing key computational chemistry insights to aid in the development of AI/ML models for drug discovery
  • The growth of the Computational Chemistry team
You will teach…
  • Key computational chemistry principles to your cross-disciplinary colleagues from Medicinal Chemistry, AI Research, Machine Learning Engineering, Cell Biology, and Pharmacology
You will learn…
  • Medicinal Chemistry
  • AI/ML applied to drug discovery
You will improve…
  • Our existing process for progressing from computational hit to experimental hit to lead to drug candidate
Within 1 month you will…
  • Propose a few hundred virtual hits to the Medicinal Chemists for synthesis
Within 3 months you will…
  • Progress a virtual hit to a biochemical/cellular hit
  • Co-author provisional patents on hit scaffolds
Within 6 months you will…
  • Validate a cellular hit in a clinically relevant animal model of disease
  • Update provisional patents with the animal model data
Within 12 months you will…
  • Nominate a lead candidate for progression into IND-enabling studies
  • Grow the Computational Chemistry team
Compensations & benefits
  • Extremely generous equity package coupled with competitive salary
  • Healthcare benefits
  • Generous vacation and parental leave
  • Super cool team building activities
  • Flexible work schedule
  • Great colleagues

Lead, Computational Chemistry Cambridge, MA / Computational Chemistry
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